ECP for dog spay incontinence?

Hi! I have a 5yr old female lab. She was diagnosed 7 months ago with Addison's Disease after having an Addisonian crisis. She is currently receiving daily prednisone & monthly injections of percorten. Also, she has spay incontinence. She was diagnosed shortly after she turned 1. We have tried proin & DES but neither worked. Recently our vet gave her a shot of ECP (estradiol cypionate). We were unaware of the serious side effects & are now extremely concerned she'll have bone marrow suppression.

  • Vetinfo

    By: Julie Ann El Segundo, CA

    Replied on 04/19/2011

    ECP used long term for urinary incontinence would make me very nervous. I would check the dose of the PROIN (phenylpropanolamine) to be sure it was high enough. It is usually given twice daily but I have known of a few instances where it was increased to three times daily. Sometimes PROIN combined with low doses of DES can be effective. I would also check that the prednisone dose being given is no higher than what she needs to maintain her Addison's disease. DO NOT change your dog's prednisone dose without consulting with your veterinarian. If all of those combinations still are not doing the job I would suggest consulting a veterinary internal medicine specialist for additional information. If there is not one in your area your veterinarian could consult with one of the veterinary schools and may also want to check VIN (the Veterinary Information Network) which has specialists from across the world answering questions for veterinarians. It is a fabulous resource. Julie, Vet Tech

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