Trilostane for Dogs

Trilostane is a treatment for dogs with Cushing's Disease. Dogs with Cushings exhibit symptoms including:

  • Lethargy
  • Excessive urination
  • Excessive thirst/hunger
  • Hair loss

Many of these symptoms are mistaken for old age and other age or breed related causes. Once diagnosed your dog can start using Trilostane to control symptoms and stop the progression of the disease. When starting any new medication or treatment with your pet watch for signs of side effects and understand the risk involved with the treatment. Alert your vet to any changes in symptoms or behaviors and take your dog in at the side of any life threatening symptoms, such as vomiting, blood in vomit or stool or loss of consciousness.

How Trilostane Works for Dogs

Trilostane affects the imbalance of the hormone Cortisol which is released by the adrenal glands. The treatment helps balance the hormone levels to provide relief and control Cushing's over the long term. While many vets have used Trilostane for years, the FDA has also approved it for the treatment of Cushing's in dogs. While Cortisol is a needed hormone in the body, excessive Cortisol puts the body in a state of extreme stress at all times. This can effect your dogs liver and kidney function, as well as the imbalanced adrenal gland. All body systems can be effected by an increased level of the stress hormone. 

Risks & Side Effects of Trilostane for Dogs

As with all medications there are risks and potential side effects. Though side effects and risks exist, they are rare with the use of Trilostane and vets and dog owners have seen much success with its use. The side effects include:

  • Lethargy
  • Loss of Appetite
  • Weakness
  • Vomiting
  • Diarrhea

These can reflect the symptoms of Cushing's your dog has been exhibiting, so if your dog is suffering from these symptoms work with your vet to determine if they are side effects from the treatment or if the treatment is not working.

The risk of Trilostane is complete failure of the adrenal gland which is permanent. This is only in about 2 to 3% of dogs, but will mean hormone replacement treatment for the life of your pet.

The Damage of Excessive Cortisol

Cortisol is a hormone that can cause stress on your dogs body. The same as how we're affected by too much Cortisol in the body. The symptoms experienced are similar to those as a dog in an extremely stressful situation and thus often misdiagnosed. Increased levels of stress hormone can also cause your dog to exhibit symptoms including:

  • Digestive problems
  • Depression
  • Appetite loss
  • Weight loss

Along with other other results of too much stress.

Cushing Disease can be difficult to diagnose as the symptoms reflect many of the same symptoms as aging. Regardless of your dogs age you should report any changes in behavior or symptoms you notice. A simple blood test and visit to your vet can determine if your dog has Cushing's. Treatment with Trilostane can bring your dog back to his energetic self in a short period of time.