Prescription Flea Medication for Cats

Flea medication for cats can be purchased in both over-the-counter and prescription format. While over-the-counter flea medications are certainly effective, prescription flea medications often tend to be more effective. They're typically more capable of preventing other conditions beside flea infestation and warding off types of insects, which can reduce the probability of developing insect-related health conditions. Here are some of the most common prescription flea medications available for cats.


The active ingredient in Revolution is selamectin. The greatest advantage of using Revolution as a flea preventative for cats is that it also offers protection against ear mites, heartworms, roundworms and hookworms, providing for extra strength protection in one medication. It is a prescription flea medication which is administered on the skin monthly, where it is absorbed and makes its way into the bloodstream. Revolution is highly effective at controlling fleas because it kills both adult fleas and prevents flea eggs from hatching, thereby preventing re-infestation.


Capstar flea preventative for cats is marketed as one of the fastest-acting prescription flea medications on the market. The active ingredient in Capstar, nitenpyram, is said to kill adult fleas within 30 minutes of administration, which is much faster than that of most other flea remedies. This product is typically used as a one-time solution for severe flea infestations, with the effects of the medication lasting no more than 24 hours. In order to consistently prevent flea infestations with Capstar, cat owners should use a supplemental, long-term flea regimen.


The active ingredient in ProMeris is metaflumizone, which works on the nervous system of fleas by paralyzing and interrupting the reproductive process. It can be administered once a month to help eliminate a flea infestation and prevent future infestations. One of the best advantages to using ProMeris is that it is waterproof, so it won't interfere with routine bathing and grooming.

Program® Flea Killer for Cats

The active ingredient in Program Flea Killer is lufenuron, which is an insect development inhibitor (IDI). Insect development inhibitors work by interfering with the life cycle and reproductive process of fleas, which is another method for controlling the reproduction and re-infestation of fleas in cats. Given monthly, Program Flea Killer is a highly productive flea medication.

Bio Spot® Spot On

Bio Spot Spot On is a flea and tick killer that works within 24 hours. Not only does this flea medication for cats kill off adult fleas and ticks, but it also includes an Insect Growth Regulator (IGR), which stops the development of immature fleas. Because Bio Spot includes an IGR, it can continuously stop breeding and reproduction of fleas from occurring. As an added benefit, Bio Spot for cats is also able to repel and kill mosquitoes, which is an added level of protection that most other cat flea medications do not have.