I have a 8 year old 4 pound Yokshire dog that had a seizure

She had another seizure and I gave her .30ml of PHENOBARBITAL .10, .15 then .5 before it took effect. How long should it take her for it to wear off. It has been almost 12 hours and she is still out of it.

  • Vetinfo

    By: Kara McCarty El Segundo, CA

    Replied on 04/19/2011

    If you have the Phenobarbital Elixir (liquid) there are two different concentrations, 15mg/5ml (3mg/ml) or 20mg/5ml (4mg/ml). A normal dose is 1mg per pound twice daily. It can be increased up to 9mg to 10mg per pound twice daily, but that should be done slowly. At 8 pounds she shouldn't receive more than 80mg at a time. If she's routinely receiving 0.3mls twice daily then I'm assuming she is taking the 20mg/5ml concentration. At that concentration she received 5.4mg of Phenobarbital which is within the accepted dose range and should not be toxic. Peak levels would be 4 to 8 hours after dosing and half of the drug should be gone from her body in 2 days. Because she received roughly 5 times her normal dose she may be out of it for at least 2 to 4 days. This is assuming normal kidney and liver function. Do not give her any more Phenobarbital until she has a level checked by her veterinarian. I would recommend that she have a physical exam, bloodwork checked and be hospitalized for supportive care (iv fluids at least) as she may get dehydrated being out of it for so long and fluids will help flush the drug out more quickly. In the future you might want to discuss alternatives to repeated Phenobarb dosing for status epilepticus.

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